TISSUE FROM A WOOLLY MAMMOTH, w h o last walked the Siberian steppes some 40,000 years ago, would not seem to be a likely source of DNA for sequence analysis. After all, DNA breaks down very readily, and even though the mammoth had been frozen in the Siberian ice until it was chipped out about 10 years ago, its DNA had undergone extensive degradation. With the aid of a new gene amplification me...

A model for dynamic independent component analysis is introduced where the dynamics are driven by score of pseudo likelihood with respect to rotation angle innovations. While conditional second moments invariant rotations, higher not, which may have important implications applications. The maximum estimator shown be consistent and asymptotically normally distributed. simulation study reports go...

To develop a conventional ultrasound (US) modified Thyroid Imaging Reporting and Data System (mTI-RADS) to stratify the malignancy risk of thyroid nodule in coexisting Hashimoto's thyroiditis (HT). The study included 138 malignant and 292 benign thyroid nodules confirmed by cytological or histopathological results. The risk score (RS) for each significant US feature was estimated by multiplying...

OBJECTIVE Reduced mental health (MH) is prevalent in rheumatoid arthritis (RA). Although longitudinal studies are limited, there is evidence that depression is associated with worse disease outcomes. We evaluated reciprocal relationships between MH, RA severity, and genetic risks for depression for 2 years in a well-characterized cohort of RA patients. METHODS We evaluated 520 early RA patien...

Pointwise products and quotients, defined in terms of barycentric and trilinear coordinates, are extended to products P ·Γ and quotients Γ/P, where P is a point and Γ is a curve. In trilinears, for example, if Γ0 denotes the circumcircle, then P ·Γ0 is a parabola if and only if P lies on the Steiner inscribed ellipse. Barycentric division by the triangle center X110 carries Γ0 onto the Kiepert ...

Dna2 was first characterized in yeast as an essential gene encoding a protein with both helicase and endonuclease activities involved in maturation of Okazaki fragments during DNA replication. Dna2 also plays a role in double-strand break (DSB) repair by homolo-gous recombination. The respective contributions of its replication and/or repair functions toward cell viability and resistance to gen...