نتایج جستجو برای: mitochondrial gene
تعداد نتایج: 1242948 فیلتر نتایج به سال:
Background and purpose: Anti-apoptotic protein Bcl-2 prevents apoptosis through the mitochondrial pathway and high-level expression of Bcl-2 is required for survival of chronic lymphocytic leukemia (CLL). Berberine (BBR) is an alkaloid that induces apoptosis of cancer cells via mitochondrial pathways. The aim of this study was to investigate the effect of Berberine on Bcl-2 gene expression in p...
Introduction: Hearing loss is the most frequent sensory disorder occurs in 1/1000 newborns. About 50% of hearing loss cases are due to genetic causes. Mutation in MTRNR1(A1555G), MTTL1(A3243G) and MTTS1(A7445G) are known to be one of the important cause of nonsyndromic Sensorineural hearing loos in some populations. This study aims to demonstrate the frequency of three mitochondrial mutatio...
Mitochondria as a source of energy production and oxidative stress can be affected by aerobic exercise. The aim of present study was to investigate the effect of aerobic training and octopamine on the gene expression of Drp-1 and Mfn-1 and MDA concentration in liver of male rats fed with repeated heated oil. Methods: 15 male wistar rats were randomly divided into five groups, healthy control g...
background: interest in tatera indica rodent arises mostly because it is believed that this species is survived among four subspecies reported from iran, two of which exist in khuzestan province. in addition, it might has a role as reservoir hosts of zoonotic cutaneous leishmaniasis in the transmission of leishmania major in some of the widespread asian foci including southwestern iran. method...
Mitochondrial DNA Maintenance Disorders: Impact of Impaired Deoxynucleoside Triphosphates Metabolism
The maintenance of mitochondrial DNA (mtDNA) is dependent upon several nuclear gene-encoded proteins including enzymes forming the replisome needed to synthesise mtDNA. These need be present in balanced quantities function properly. In addition, mtDNA synthesis requires a supply nucleotides that achieved by nucleoside recycling inside mitochondria, and nucleotide import from cytosol. Mitochondr...
Gene editing of the mitochondrial genome using CRISPR-Cas9 system is highly challenging mainly due to sub-efficient delivery guide RNA and Cas9 enzyme complexes into mitochondria. In this study, we were able perform gene in DNA by appending an NADH-ubiquinone oxidoreductase chain 4 (ND4) targeting transport-derived stem loop element (RP-loop) expressing with a preceding localization sequence. W...
this study pursued the molecular identification of fish species from processed products for human consumption which, a priori, belonged to nine species. dna barcoding using direct sequencing of about 650 bp of the mitochondrial gene cytochrome oxidase subunit i (coi) revealed incorrect labeling in the three alaska pollack samples (11% of all samples). substitution of fish species constitutes se...
Background: Based on the studies, variation in the mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes is associated with increased susceptibility to diseases including cancer. Opiate abusers are at high risk for diseases. In this study, we measured the mtDNA copy number in peripheral blood leukocytes in a group of opiate abusers compared with those in healthy individuals. Met...
Defects in mitochondrial function activate compensatory responses the cell. Mitochondrial stress that is caused by unfolded proteins inside organelle induces a transcriptional response (termed “mitochondrial protein response” [UPRmt]) mediated activating transcription factor associated with 1 (ATFS-1). The UPRmt increases quality control. dysfunction frequently causes defects import of proteins...
OPA1 is a dynamin-family GTPase that the central mediator of mitochondrial inner membrane fusion. The Opa1 gene generates both long and short isoforms (l-OPA1 s-OPA1) through proteolytic processing. We identify new s-OPA1 show it functions with l-OPA1 to tune level
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