Insecticides allow control of agricultural pests and disease vectors and are vital for global food security and health. The evolution of resistance to insecticides, such as organophosphates (OPs), is a serious and growing concern. OP resistance often involves sequestration or hydrolysis of OPs by carboxylesterases. Inhibiting carboxylesterases could therefore restore the effectiveness of OPs fo...

Although urinary excretion levels of dialkyl­ phosphates (DAPs)—which are metabo­ lites and environmental degradates of OP insecticides—are useful as quantitative indi­ cators of exposure to OPs in agricultural workers, they are not as useful for the gen­ eral population. For agricultural workers, the source of the OP and time of exposure are typically known, and there is substan­ tial exposure...

Organophosphorus (OP) compounds are organic derivatives of phosphorus that have largely been used as pesticides and nerve agents. Tetraethylpyrophosphate was synthesized in 1854 as the first OP cholinesterase inhibitor. During 1934–1944, Gerhard Schrader, a German chemist at I. G. Farben industries and his coworkers synthesized about 2,000 OP compounds, including parathion as a pesticide and ta...

The Salinas River is the largest of the three rivers that drain into the Monterey Bay National Marine Sanctuary in central California (USA). Large areas of this watershed are cultivated year-round in row crops, and previous laboratory studies have demonstrated that acute toxicity of agricultural drain water to Ceriodaphnia dubia is caused by the organophosphate (OP) pesticides chlorpyrifos and ...

BACKGROUND Nitric oxide synthase (NOS) genes are candidates for Parkinson's disease (PD) because NOS enzymes produce nitric oxide (NO), a pro-oxidant that can damage neurons. Widely used organophosphate (OP) pesticides can induce oxidative stress and are reported to increase PD risk. Additionally, two single nucleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the abilit...

The qualitative morphologic study of the effects of organophosphate agents on development of neural cells in culture is a promising approach as a primitive step for further physiologic, electro physiologic and molecular investigation. Parathion is an OP (Organophosphate) used as an agricultural insecticide. Improper handling of this agent causes poisoning characterized by convulsive seizures, w...

The qualitative morphologic study of the effects of organophosphate agents on development of neural cells in culture is a promising approach as a primitive step for further physiologic, electro physiologic and molecular investigation. Parathion is an OP (Organophosphate) used as an agricultural insecticide. Improper handling of this agent causes poisoning characterized by convulsive seizures, w...