نتایج جستجو برای: talalay method

تعداد نتایج: 1630168  

Journal: :BMC Cancer 2021

Abstract Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated INI-43 before treatment cisplatin, and MTT cell viability apoptosis assays performed. Activity localisation p53 NFκB was determined after co-tre...

Journal: :The Biochemical journal 1998
J J Martinez-Irujo M L Villahermosa J Mercapide J F Cabodevilla E Santiago

Different methods for studying the concurrent effects of two linear inhibitors on a single enzyme have been published, including the fractional product of Webb, the Yonetani-Theorell plot or the method of Chou and Talalay. Recently the use of combination plots has also been advocated for this purpose. We have evaluated the applicability of these methods and found that most of them depend on ass...

Journal: :Biometrics 2010
Violeta G Hennessey Gary L Rosner Robert C Bast Min-Yu Chen

In this article, we propose a Bayesian approach to dose-response assessment and the assessment of synergy between two combined agents. We consider the case of an in vitro ovarian cancer research study aimed at investigating the antiproliferative activities of four agents, alone and paired, in two human ovarian cancer cell lines. In this article, independent dose-response experiments were repeat...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه لرستان - دانشکده علوم پایه 1389

abstract part one: the electrode oxidation potentials of a series of eighteen n-hydroxy compounds in aqueous solution were calculated based on a proper thermodynamic cycle. the dft method at the level of b3lyp-6-31g(d,p) was used to calculate the gas-phase free energy differences ,and the polarizable continuum model (pcm) was applied to describe the solvent and its interaction with n-hydroxy ...

پایان نامه :0 1370

all analytical methods are generally based on the measurement of a parameter or parameters which are somehow related to the concentration of the species.an ideal analytical method is one in which the concentration of a species can be measured to a high degree precision and accuracy and with a high sensitivity. unfortunately finding such a method is very difficult or sometimes even impossible.in...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده ادبیات و زبانهای خارجی 1393

for several years, researchers in familiarity of efl teachers with post-method and its role in second and foreign language learners’ productions have pointed out that the opportunity to plan for a task generally develops language learners’ development (ellis, 2005). it is important to mention that the critical varies in language teaching was shown is the disappearances of the concept of method ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سمنان 1392

in the area of vocabulary teaching and learning although much research has been done, only some of it has led to effective techniques of vocabulary teaching and many language learners still have problem learning vocabulary. the urge behind this study was to investigate three methods of teaching words. the first one was teaching words in context based on a traditional method of teaching that is,...

Background and purpose: Nowadays, multi-drug regimens or combination therapy are new approaches in cancer treatment that combine two or several therapeutic agents. Combination therapy aims at improving the therapeutic efficacy of anticancer drugs while reducing toxicity and preventing drug resistance. The aim of this study was to determine the synergistic effect of combined clarithromycin and d...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعت آب و برق (شهید عباسپور) - دانشکده مهندسی برق و کامپیوتر 1392

abstract according to increase in electricity consumption in one hand and power systemsreliability importance in another , fault location detection techniqueshave beenrecentlytaken to consideration. an algorithm based on collected data from both transmission line endsproposed in this thesis. in order to reducecapacitance effects of transmission line, distributed parametersof transmission line...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم پایه دامغان 1389

in this thesis, ‎‎using‎‎ ‎concept‎s‎ ‎of‎ ‎wavelet‎s‎ ‎theory ‎‎‎som‎e‎ ‎methods‎‎ ‎of‎ ‎th‎e ‎solving‎‎ ‎optimal‎‎ ‎‎con‎tr‎ol‎ problems ‎(ocps)‎‎. ‎g‎overned by time-delay systems is investigated. ‎th‎is‎ thesis contains ‎tw‎o parts. ‎‎first, the method of obtaining ‎o‎f ‎the‎ ‎‎ocps‎ in time delay systems by linear legendre multiwavelets is ‎ ‎presented‎.‎‎‎‎ the main advantage of the meth...

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