ipomoea reniformis roxb. (convolvulaceae) is a small, weedy herb used for the management of cardiac problems in traditional systems of medicine in india and pakistan. objective of the present study is to investigate the hypotensive, diuretic and angiotensin converting enzyme (ace) inhibitory activities of the aqueous-methanol (30:70) crude extract of the dried aerial parts of i. reniformis (ir....

There is growing evidence that oxidative stress contributes to the pathogenesis of hypertension. Our aim was to measure oxidative stress in hypertensive subjects, and assess the potential confounding influences of antihypertensive therapy. Serum malondialdehyde and antioxidant levels were estimated in patients at the time of presentation and also after a antihypertensive therapy for 3 months. D...

Saffron petal is the main by-product of saffron processing which produced at high level but it is not applied and thrown out. Saffron petal is containing of several compounds such as mineral agents, anthocyanins, flavonoids, glycosides, alkaloids and kaempferol. As saffron petal is cheaper and produces in large amounts compared to saffron stigma, so, it can be considered as an appropriate sourc...

otostegia persica (burm.) boiss. is used for the treatment of various diseases in traditional medicine. the aim of this study was to assess the effects of hydroalcoholic extract of the aerial parts of o. persica in dexamethasone (dex) induced hypertension in male wistar rats. for induction of hypertension, dex at 30 µg/kg/day was administered subcutaneously for 14 days. in a prevention study, a...

a complicated and controversial subject in obstetrics i.e., toxemia of pregnancy is looked upon, both from an anesthesiological and obstetrical point of view. as pre-eclampsia and eclampsia involve immediate treatment and obstetric considerations, the choice between epidural and general anesthesia becomes necessary when cesarean section is contemplated. apart from the pathophysiology of the ves...

Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...