In an earlier study (Alexander et al., 1974) it was shown that the mineral mixture used in association with a synthetic diet was deficient in zinc, copper, iron, and manganese. A new mixture containing appropriately increased amounts of these trace metals has now been evaluated by means of metabolic balance studies carried out on children with phenylketonuria. This new mixture was shown to be s...

The prion protein (PrP) binds copper and has antioxidant activity enhancing the survival of neurones in culture. The ability of the PrP to bind other cations was tested and it was found that only manganese could substitute for copper. Although initially manganese-loaded PrP exhibited similar structure and activity to copper-loaded PrP, after aging, manganese-loaded PrP became proteinase resista...

in this study, the concentrations of heavy metals (ca, zn, cu, fe, mn, ni) in thesediment of shavoor river in khuzestan province in iran has been investigated. after the library studies and field studies, six samples of water and sediment were taken from the river in order to evaluate heavy metal pollution in sediments. to determine the geochemical phases of metals in sediment samples the 5-ste...

Recently, iron deficiency has been connected with a heterogeneous accumulation of manganese in the rat brain. The striatum is particularly vulnerable, for there is a significant negative correlation between accumulated manganese and gamma-aminobutyric acid levels. The effect of dietary iron deficiency on the distribution of zinc and copper, two other divalent metals with essential neurobiologic...

The essential trace elements zinc and manganese have been noted as factors in brain disease since the Twenties. The combined use of zinc and manganese in schizophrenia is based on: 1) Increased urinary excretion of copper when both zinc and manganese are given orally 2) Zinc alone causes a decrease in blood manganese and 3) The double deficiency of zinc and manganese frequently is found in pati...