The use of endurance regimens could be improved by defining their respective effectiveness on aerobic fitness and brain health that remains controversial. We aimed at comparing work-matched high-intensity interval training (HIIT) with moderate-intensity continuous (MICT) performance muscular plasticity markers in healthy rats. Cognitive functions were also investigated following the 8-week trai...

Recent studies highlighted the importance of loop 2 of α1 glycine receptors (GlyRs) in the propagation of ligand-binding energy to the channel gate. Mutations that changed polarity at position 52 in the β hairpin of loop 2 significantly affected sensitivity to ethanol. The present study extends the investigation to charged residues. We found that substituting alanine with the negative glutamate...

Recent research has shown a negative correlation between marbling and serum retinol concentration in Japanese Black cattle. Three hundred sixty single-source black, yearling steers (average initial BW = 316 ± 9.1 kg) fed a 91 % concentrate (steam-flaked corn base) diet were used to evaluate the effects of supplemental vitamin A concentration on performance, DMI, and carcass traits. Steers were ...

Botulinum neurotoxins (BoNTs A-G) are zinc metalloendoproteases that exhibit extraordinary specificities for proteins involved in neurotransmitter release. In view of the extreme toxicities of these molecules, their applications in human medicine, and potential for misuse, it is of considerable importance to elucidate the mechanisms underlying substrate recognition and to develop inhibitors, wi...

OBJECTIVE To identify and characterize hospital admissions and readmissions in the Brazilian Unified Public Health System (Sistema Único de Saúde [SUS]) in children with sickle cell disease diagnosed by the Minas Gerais Newborn Screening Program between 1999 and 2012. METHODS Hospital Admission Authorizations with the D57 (International Classification of Diseases-10) code in the fields of pri...