biodegradable polymeric nanoparticles (nps) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. icd-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit anti-cancer activity. in this report polymer based sodium alginate nanoparticles of icd-85 was used to enhance its therapeutic effects and redu...

Autophagy and apoptosis are closely associated. In previous studies, pseudolaric acid B (PAB), a diterpene acid isolated from the root and trunk bark of Pseudolarix kaempferi Gordon (Pinaceae), was demonstrated to induce apoptosis in various cell lines. However, in L929 murine fibrosarcoma and SW579 human thyroid squamous cell carcinoma cells, only autophagy was induced. In the present study, a...

objective: cancer is a major health problem worldwide and current therapies for cancer are often limited by short-term efficacy due to drug resistance. there has been much interest in the use of naturally occurring compounds with chemo-preventive and chemotherapeutic properties in the treatment of cancers. rose is one of the most important groups of ornamental plants which their fruits and flow...

background: functional defects in mitochondria are involved in the induction of cell death in cancer cells. the process of programmed cell death may occur through the mechanisms of apoptosis. several potential lead molecules such as camptothecin (cpt) and its analogues have been isolated from plants with anticancer effect. the aim of the present study was to understand the necrotic effect versu...

Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...

A simple and efficient synthesis of novel, D-ring substituted estrone derivatives containing a 16α-triazolyl moiety is described. Two epimeric azido alcohols (16α-azido-17α-hydroxy and 16α-azido-17β-hydroxy) of estra-1,3,5(10)-triene-3-methyl ether were prepared, followed by copper(I)-catalyzed azide-alkyne cycloaddition with various terminal alkynes. The steroidal triazoles were obtained in hi...

Encephalitozoon cuniculi is an obligate intracellular, spore-forming parasite belonging to the microsporidia that can cause disseminated infection in immunocompromised persons. E. cuniculi spores infect host cells by germination, i.e., by explosively everting the polar filament, through which the spore contents (sporoplasms) are subsequently injected into the cytoplasm. In addition, we observed...

The secretome proteins of Paenibacillus polymyxa Kp10 and Lactococcus lactis Gh1 were previously found to have the potential for controlling antibiotic-resistant pathogen. Therefore, their safety evaluation ensure consumer health is deemed important. This study was evaluate toxicity effect both in human cells against Medical Research Council cell strain 5 (MRC5). Then, antibacterial activities ...

Objective: Perovskia abrotanoides Karel, belongs to the family Lamiaceae and grows wild alongside the mountainous roads inarid and cold climate of Northern Iran. The anti-tumor activity of P. abrotanoides root extract has been shown previously. This study was designed to examine in vitro anti-proliferative and pro-apoptotic effects of flower extract of P. abrotanoides on MCF-7 and Hela cell lin...