Objective(s): The aim of this study is to explore the potential neuroprotective effects of Ginkgolide B (GB), a main terpene lactone and active component in Ginkgo biloba, in hypoxia-induced neuronal damage, and to further investigate its possible mechanisms.Materials and Methods: 54 Sprague-Dawley rats were randomly divided into three groups: the untreated control group (n=18); the hypoxia gro...

Vicia genus has 45 species in Iran. Many protective and biological activities have been reported from these species.  In spite of many works, nothing is known about protective effect of V. cracca against hypoxia conditions. In this study, protective effects of V. cracca extract against hypoxia-induced lethality in mice were evaluated by three experimental models of hypoxia, asphyctic, haem...

Background: There are reports indicating that among the others, hypoxia is one of the testes threatening factors, which may occur intentionally or accidentally. Hypoxia could be created secondarily after some pathological conditions such as anemia. In this study we aimed to investigate the crocin protective effect on the testes parameters in the animals that were exposed against phenyl hydrazin...

to investigate the influence of hypoxia during the early stage of incubation on embryonic developmentand hatching events, and consequently on incidence of ascites in broiler chickens, one thousand fertile eggswere incubated in two commercial incubators. half the eggs were incubated in a low altitude incubator untilhatched. the second half were incubated in a high altitude incubator until day 10...

background: the rationale was to develop an ablation approach to destroy regions of tumor resistant to radiation and thus reduce the time required for whole tumor ablation, while improving overall tumor control after radiotherapy. materials and methods: the system is composed of a micro positron emission tomography (mpet), 7t magnetic resonance imaging (mri), and a customized mri-compatible foc...

central anticholinergic syndrome (cas) following general anesthesia (ga) is a well known syndrome in children and adults. many cases of cas have been previously reported in the literature. however, there are only two reports of post resuscitation cas after administration of small doses of atropine. hereby, we report a case of cas in a child undergoing complete dental restoration under ga after ...

Myocardial infarction (MI) is the most prevalent disease with severe mortality, and hypoxia-induced cardiac injury cardiomyocyte apoptosis are significant harmful consequences of this disease. The cross talk between hypoxia signaling glycolysis energy flux plays a critical role in modulating MI-related heart disorder. However, underlying mechanism remains unclear. Here, we aimed to explore effe...

the acute diffuse hypoxia in dogs by general hypoxia, ligation of the coronary arteries and perfusion of the coronaries in the diffuse hypoxic hear ts. t he results of our experiments suggest that the quantitative diminu tion of oxygen and bloo d supply to the myocardium is, rather than oxygen differential , a determining fa ctor for development of ventr icular fi brillat ion or cardiac arrest.

objective(s): scutellarin, a flavonoid extracted from the medicinal herb erigeron breviscapus hand-mazz, protects neurons from damage and inhibits glial activation. here we examined whether scutellarin may also protect neurons from hypoxia-induced damage. materials and methods: mice were exposed to hypoxia for 7 days and then administered scutellarin (50 mg/kg/d) or vehicle for 30 days cognitiv...