Psoriatic onychodystrophy affects up to 50% of patients with psoriasis and 80% psoriatic arthritis, an estimated lifetime risk nail plate changes in this patient population 90%. Nail is characterised by a variety morphological resulting from the inflammation matrix or bed, leading functional impairment negative impact on patient’s quality life. distinct therapeutic problem, as its localization ...

BACKGROUND: Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evidence that psoriatic plaque itself may serve as a...

Psoriasis is a chronic inflammatory disorder characterized by an erythematous scaly plaque of the skin and is occasionally accompanied by systemic complications. In the psoriatic lesions, an increased number of cytokine-producing dendritic cells and activated T cells are observed, which indicate that psoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging stu...

OBJECTIVES This study aimed to investigate and compare the prevalence of oral mucosal lesions in a group of psoriatic patients and healthy subjects, and its correlation to multiple clinical parameters. STUDY DESIGN 100 psoriatic patients and 100 closely matched controls underwent clinical oral examination. Oral lesions were diagnosed according to the criteria proposed by the World Health Orga...

Psoriatic arthritis is a psoriasis-related spondyloarthropathy that occurs in 20-30% of patients with psoriasis. Various imaging studies have demonstrated that there is a considerable proportion of undiagnosed psoriatic arthritis among patients with psoriasis. Since early detection and treatment of psoriatic arthritis could, ultimately, allow the prevention of clinical and radiologic progressio...

Objective: To report alopecia universalis (AU) as an adverse effect of adalimumab that has not yet been documented in literature. Case Summary: A 50-year-old male was diagnosed with psoriasis and psoriatic arthritis and was commenced on adalimumab subcutaneous injections biweekly. The psoriatic skin lesions and arthritis showed improvement. However, one year later he lost all his body hair incl...