The color developing reaction between ambrisentan and 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ) or 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CLA) was successfully employed in the development of two simple and sensitive spectrophotometric methods (M1 and M2) for the determination of ambrisentan in its pharmaceutical dosage forms.The methods are based on the charge transfer reaction of ...

Accurate estimating is one of the most important activities in the field of software project management. Different aspects of software projects must be estimated among which time and effort are of significant importance to efficient project planning. Due to complexity of software projects and lack of information at the early stages of project, reliable effort estimation is a challenging issue. ...

Background: Salmonella can cause serious human gastroenteritis and is frequently isolated from various food samples. The cell culturing, immunoassay, and polymerase chain reactions (PCR) are the current methods to detect such pathogenic agents. However, these methods are time-consuming and labor-intensive, and thus unavailable for rapid-monitoring of Salmonella</em...

Agile approaches to software development provide flexibility within the method, but provide little or no flexibility to support software process improvement (SPI). This second kind of flexibility is important to permit organizations to improve with time. To accomplish such improvement, a method-engineering approach is shown here to be useful. Examples of the application of method engineering to...

Functionality is a measure of how well a system does the work it was intended to do, but functionality is not all that matters in software development. Properties like interoperability, modifiability, and portability also matter as much as functionality does. These properties are determined primarily by the software structure – or the software architecture. While many structures can satisfy fun...

A Dutch hospital had a problem with the planning of their Short Stay department and asked for a scheduling support system. In this paper, we describe the development of this system. We describe techniques from Operations Research and Artificial Intelligence (AI) that can be used to model the situation. We have used the AI-techniques because we believe a user-oriented approach is required to dev...