Thallium (Tl) is one of the most toxic heavy metals affecting both humans and animals, yet least studied for its toxicological effects. A total 40 male Wistar rats were randomly divided into four Groups with 10 in each Group. Group I received distilled water only served as a control. II, III, IV thallium sulfate (I) at 0.48, 0.93, 1.33 mg/kg body weight, respectively, drinking 90 days. In rats,...

Objectives: The current preclinical study aimed at appraising the claim of anti diarrheal activity, acute and sub chronic oral toxicity of the polyherbal formulation Entoban to acknowledge its safety and efficacy. Methods: In order to investigate the antidiarrheal activity albino mice were treated with Entoban at doses of 2.5, 5, 10 mg/kg. For evaluation of acute toxicity the animals were treat...

Objective(s): Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs), therefore regulatory health risk assessment has become necessary for the saf...

Abstarct: Use of herbal medicines prevails in rural and urban areas of the world; especially for treating ailments which allopathic medicines fail to treat. Present study was undertaken for the pharmacological and toxicological evaluation of Mucuna pruriens, Cinnamomum zeylanicum, and Myristica fragrans, alone and in combination. The acute toxicity was studied on mice and sub chronic toxicity a...

Explanation.................................................................................................. 316 Evaluation for acceptable daily intake......................................................... 316 Biochemical aspects ....................................................................... 316 Absorption, distribution and excretion.................................. 316 Biotransfo...

In the present study, the safety profile of Trichosanthes dioica root was evaluated by acute and sub-chronic toxicity study of the hydro alcoholic extract of T. dioica root (TDA) in Swiss albino mice. The oral median lethal dose (LD ) of TDA was found to be 2800 mg/kg body weight. For sub-chronic toxicity study 50 TDA was administered at the single daily dose of 10 mg/kg for 28 consecutive days...

Explanation.................................................................................................. 149 Evaluation for acceptable daily intake......................................................... 150 Biochemical aspects........................................................................... 150 Absorption, distribution and excretion ....................................... 150 B...

Berberis vulgaris and berberine, its main component, traditionally have been used for treatment of various disorders. The pharmacological properties of them have been investigated using different in vivo and in vitro models. In spite of beneficial effects of B. vulgaris on different cell lines, there are documents have revealed negative impacts of it on animal and human. In this regards, the de...