نتایج جستجو برای: by using novel single step
تعداد نتایج: 9227479 فیلتر نتایج به سال:
a novel single step double positive double negative selection strategy for β-globin gene replacement
introduction: beta thalassemias are a heterogenous group of autosomal recessive disorders, characterized by reduced or absent production of the b-globin chain by the affected allele. transplantation of allogenic hematopoietic stem cells (hsc) is a curative approach but this therapeutic option is not available to the majority of patients. transplantation of genetically corrected autologous hsc i...
We have demonstrated a simple and efficient route for the synthesis of a novel imine based tridentate ligand and its Pd-complex to investigate the C-C cross-coupling reactions, that involve column chromatography purification in only one step. The catalytic activity of the newly synthesized catalyst was studied for the Suzuki, Sonogashira and, Heck cross-coupling reactions under mild conditions....
Cell-to-cell gene expression variability is an inherent feature of complex biological systems, such as immunity and development. Single-cell RNA sequencing a powerful tool to quantify this heterogeneity, but it prone strong technical noise. In article, we describe step-by-step computational workflow that uses the BASiCS Bioconductor package robustly within between known groups cells (suc...
this thesis is presented 10 ghz voltage controlled ring oscillator for high speed application. the voltage controlled ring oscillator was designed and fabricated in 0.13یm cmos technology. the oscillator is 7-stages ring oscillator with one inverter replaced by nand-gate for shutting down in the ring oscillator during idle mode. tri-state inverter was used to control of 126 bit vector in ri...
this study gives a rough notional method to find their textual placing and valuating in the text, narrows the board of vision to mystic items and finally lists the strategies used by the translators of mathnawi to present solutions for preserving the additional values. at last, as the sum-up, strategies in comparison would be presented. it should be noted that by extending the translations from...
the major purpose of this study was to develop the translation teacher competency test (ttct) and examine its construct and predictive validity. the present study was conducted in two phases: a qualitative phase as well as a quantitative phase. in the first phase of the study, the author attempted to find out the major areas of competency required for an academic translation teacher. the second...
now-a-days graphic design plays a major role in influencing culture, society, business, and customers, in such a way that one could look upon every individual as a potential customer. graphic designers seek to identify customers needs and find an intelligent solution for them. correct identification and understanding of those needs is the first step towards achieving ones goals. marketing knowh...
detection of brain tissues using magnetic resonance imaging (mri) is an active and challenging research area in computational neuroscience. brain mri artifacts lead to an uncertainty in pixel values. therefore, brain mri segmentation is a complicated concern which is tackled by a novel data fusion approach. the proposed algorithm has two main steps. in the first step the brain mri is divided to...
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