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Microarrays play important roles in Medicinal Chemistry and Drug Discovery. In the Premicroarray era, scientists used to study one gene at a time. This approach is costly and time consuming. Quite often, many genes that interact with each other would be ignored. Therefore, the discovery of candidate drug targets is challenging, requiring the rapid development of techniques to identify the diffe...
Utilizing Multiple in Silico Analyses to Identify Putative Causal SCN5A Variants in Brugada Syndrome
Brugada syndrome (BrS) is an inheritable sudden cardiac death disease mainly caused by SCN5A mutations. Traditional approaches can be costly and time-consuming if all candidate variants need to be validated through in vitro studies. Therefore, we developed a new approach by combining multiple in silico analyses to predict functional and structural changes of candidate SCN5A variants in BrS befo...
furrow irrigation is the most common type of surface irrigation. determine the advance and recession time in the field is required the accurate measurement and this can be costly and time consuming. winsrfr model is used for simulation furrow irrigation by zero inertia and kinematic wave engines. using this model, advance time, reaction time, infiltration depth, runoff depth and application eff...
nowadays enhancing critical thinking in learners is considered one of the foreign language teachers’ tasks due to its high position in foreign language classrooms. when it comes to selecting materials for language classrooms, there are obviously some criteria that teachers should apply. the present study aimed at a critical thinking based analysis of ten picture story books and ten folktales th...
Each system has its own definition of reliability. Reliability in mobile ad-hoc networks (MANET) could be interpreted as, the probability of reaching a message from a source node to destination, successfully. The variability and volatility of the MANET configuration makes typical reliability methods (e.g. reliability block diagram) inappropriate. It is because, no single structure or configurat...
the subjects of the study are only the tefl teachers and students at gilan university. to obtain the desired data, a questionnaire which was based on the theories and disecussions gathered, was used as the main data gathering instrument. to determine the degree of relationship between variables, covariance and pearson product moment correlation coefficient were the formulas applied. the data we...
drought is transient phenomenon , slow , repetitive and integral part of the climate of each region. drought begins with a substantial reduction in precipitation over the long-term average rainfall and over time, reduced soil moisture and surface and ground water resources will continue to decrease. this phenomenon is the most important in bakhtegan basin because of its importance in strategic ...
saluk mount is selected for devonian biostratigraphy. this area located at southwest of bojnurd. in this study three sections are selected and two sections, chahar-borj and tabar sections with a thickness of 650 m, which consist mainly of calcareous sediments was studied in detailed but third section, qelli section, with a thickness of about 450m which consist mainly of sandstone and evaporates...
there has been a gradual shift of focus from the study of rule systems, which have increasingly been regarded as impoverished, … to the study of systems of principles, which appear to occupy a much more central position in determining the character and variety of possible human languages. there is a set of absolute universals, notions and principles existing in ug which do not vary from one ...
in this study reference as one of the five cohesive devices in the achievement of textuality in english and persian narrative/descripitive written texts is focused on and analysed . to do so , the theoretical framework elaborated by halliday and hasan (1976) and its version adapted by the writer to match the sub-types of reference in farsi are applied to the analysis of reference in english and...
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