One of the main components of the stress system is hypothalamus- pituitary-adrenal (HPA) axis. Acute activation of µ-opioid receptors increases the activity of the HPA axis, leading to release of ACTH and corticosterone. Glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. In this experiment, ...

Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes. We also wanted to verify if behavioral tolerance of repeated daily restraint would be detectable in this model. Male Wistar rats were restrained for 2 ...

Benzodiazepines (BZDs) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. However, they have some undesired effects including memory problems. In continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. Previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

Portulaca oleracea (PO) overgrows in the different parts of Iran. In previous studies, ethanolic extracts of PO showed antinociceptive activity, sedative in animal. This study was designed to evaluate anxiolytic effects in different doses of the aqueous decoction extracts of PO. In this study, fourty male mice (25-30 g) were used in elevated plus maze model. Different doses of the extract. (25,...

There is growing interest in flavonoids for their wide array of biological actions. In neurodegenerative disorders these naturally occurring polyphenolic compounds, are known to inhibit proinflammatory mediators such as in TNF–? and IL-6 in lipopolysaccharide (LPS) stimulated neuronal degeneration, which are associated with Alzheimer’s and Parkinson’s disease. Recent studies on flavonoids have ...

In recently, many studies tried that fine medicinal plant that may be useful in treatment of psychological diseases. Coriandrum sativum (CS) overgrows in the different parts of Iran. In this study we investigated the effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice. In this study, fourty male mice (25-30 gr) in elevated plus maze model were used. Different do...

Background & Aims: Iron is an essential element for correct brain function. Iron deficiency changes some behaviors such as anxiety and nociception. Recently, nano-iron, Ferric or ferro oxide (nano-Fe2O3 or Fe3O4), are used in various applications in agriculture, industry and medicine, but their effects on the heath and behavior is not clear. In this study, the effects of Fe2O3 nanoparticles on ...

Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 g...