Amongst people with Cystic Fibrosis, Aspergillus fumigatus is the most frequently cultured fungal pathogen in sputum samples. Elexacaftor/tezacaftor/ivacaftor (ETI) a CFTR modulator which results significant improvements lung function. We investigated effect of ETI therapy on serological response to adult CF patients prescribed ETI. Data from 275 at least one Phe508del mutation were included.. ...

Crosslinking of the IgE receptor on rat basophilic leukemia (RBL) cells using the multivalent antigen DNP-BSA leads to a rapid and sustained increase in the filamentous actin content of the cells. Stimulation of RBL cells through the adenosine receptor also induces a very rapid polymerization of actin, which peaks in 45-60 s and is equivalent in magnitude to the F-actin response elicited throug...

IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind their antigens weakly. In this study, we find that there are two distinct pathways to generate high and low affinity IgE. High affinity IgE is generated through sequential class switching (μ→γ→ε) in which an intermediary...

A series of recent experiments from our laboratory have focused on the demonstration and characterization of a relatively IgE class-specific, nonantigen-specific, cellular suppressor mechanism involved in the murine IgE antibody response to allergens not controlled by H-2-1inked immune response (Ir) genes (1, 2). Such a suppressor T-cell mechanism was initially demonstrated indirectly by admini...

Background and Purpose: Allergy is an undesired immune response to non-pathogenic agents. However, some opportunistic microorganisms such as fungi can also cause allergy. Among those fungi, hyphae form of Aspergillus strains including A. fumigatus, A. flavus, and A. niger could be mentioned. In this study, we aimed to separate allergic proteins from Aspergillus strains and determine their ident...

The prolonged inhibition of IgE synthesis in mice caused by perinatal inoculation of IgE is attributable, at least in part, to the formation of anti-IgE antibodies. The induction of unresponsiveness with respect to IgE synthesis requires that IgE be administered during a brief interval (2 to approximately 10) days after birth, that corresponds with the time period during which anti-IgE antibodi...

BACKGROUND The convergent distribution of the Human Immunodeficiency Virus (HIV) and helminth infections has led to the suggestion that infection with helminths exacerbates the HIV epidemic in developing countries. In South Africa, it is estimated that 57% of the population lives in poverty and carries the highest burden of both HIV and helmith infections, however, the disease interactions are ...