introduction: opium addiction can change immune response to types of stress such as injury or trauma due to alterations in the in secretion status of cytokines in the body. in this study, effects of opium addiction on wound healing and post-operative adhesion bands were assessed after laparotomy. materials and methods: male rats (n=20) were randomly divided into opium addicted (documented with ...

T cells play several roles in antitumor immunity, including mediating cytotoxicity, generating immune memory, and promoting humoral immunity. Given these critical roles, are the therapeutic target of immunotherapies that have achieved clinical success, notably checkpoint inhibitors chimeric antigen receptor T‐cell therapy. However, a fraction patients benefits from treatments due to intolerable...

background: tuberculosis (tb) remains an important health problem throughout the world. despite its significance in public health, mechanisms of protective immunity against mycobacyerium tuberculosis in humans have not yet been understood. objective: to evaluate cell mediated immune response against purified ag 85, ppd and phytohemagglutinin (pha) in patients with tuberculosis and healthy tuber...

The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin li...

Cytokines and chemokines are secreted proteins involved in numerous aspects of cell growth, differentiation, and activation. A prominent feature of these molecules is their effect on the immune system with regard to cell trafficking and development of immune tissue and organs. The nature of an immune response determines which cytokines are produced and ultimately whether the response is cytotox...

Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salient features of parasitic worm infection, including parasite development throug...

this scientific report describes the effect of feeding detoxified karanj seed cake as protein replacement of soya bean meal on immunity and pathology in growing lambs. twenty-four male lambs, 4-6 months of age were divided into four groups of six each and fed with different levels of detoxified karanj seed cake (dkc 0%, dkc 25%, dkc 50%, dkc 75%) for 140 days. effect on humoral and cell mediate...