objective: to determine the effects of local administration of platelet rich plasma (prp) on peripheral nerve regeneration in rat sciatic nerve transection model. methods: forty-five male white wistar rats were randomized into three experimental groups (n = 15): normal control group (nc), silicon group (sil), prp treated group (sil/prp). in nc group left sciatic nerve was exposed through a glut...

back-bone) metabolism were significantly higher after SNMP: ribose (.22-folds, p<0.001), ribonate (.37-folds, p<0.001), and ribitol (.10.5-folds, p<0.001). Glycolysis metabolites increased during SNMP: glucose-6-phosphate (.23-folds, p=0.01), fructose-6-phosphate (.12-folds, p=0.03), and phosphorenolpyruvate (.8-folds, p=0.03). Antioxidant pathways were fully functional after SNMP: glutathione-...

Platelet-rich plasma (PRP) contains a mixture of growth factors that play an important role in wound and fracture healing. While PRP enhanced bone formation by autogenous cancellous bone grafts, its influence in combination with different bone substitutes remained unknown. This study evaluated the effect of PRP on osteogenic differentiation and ectopic bone formation of human mesenchymal stem c...

The antibiotic moenomycin(Flavomycin®)1'2'3) isolated from Streptomyces bambergiensis and other strains is a surface-active phosphorus-containing glycolipid that contains an UV-chromophore, 2-amino-cyclopentane-dione-l,34), a lipid portion, moeno cinol5) a carbohydrate moiety6) consisting of several sugars (D-glucose, D-glucosamine, D-quinovosamine), and phosphorus linked in ester form. The pre...

In the two preceding papers, evidence has been presented for the enzymatic synthesis of polyglycerophosphate (1) and polyribitol phosphate (2) from cytidine diphosphate glycerol and cytidine diphosphate ribitol, respectively. In this paper, we describe the glycosyl transfer from uridine diphosphate glucose to polyglycerophosphate by an enzyme from Bacillus subtilis. Teichoic acids differ in the...

heamophilus influenzae type-b (hib) is a gram - negative pleomorphic bacterium that causes meningitis infections in children with the age of less than 5 years particularly in two years old infants. in the present study various isolates of heamophilus influenzae from infants suspected to meningitis were collected, identified, characterized and were used throughout our experiments. different cult...

Induction studies on Aerobacter aerogenes strain PRL-R3, using ribitol as the inducer-substrate, indicated that two enzymes of ribitol catabolism, ribitol dehydrogenase and d-ribulokinase, are coordinately induced. The utilization of d-arabinose as a substrate resulted in the induction of ribitol dehydrogenase as well as d-ribulokinase. Mutants which were constitutive for ribitol dehydrogenase ...

Objective(s): Autologous bone transplantation known as the “gold standard” to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hA...