Chitosan is a natural polymer which has limited solubility. Chitosan gets solubilized at acidic pH but is insoluble at basic pH. In the present study, carboxymethyl chitosan (CMC) was prepared which shows high swelling in basic pH and thus can delay the drug release and can act as matrix for extended release formulation. CMC was characterized by FTIR and NMR. pH-sensitive hydrogels of theophyll...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

Lehninger and Schneider (1) studied the swelling of isolat,ed liver mitochondria induced by reduced glutathione (GSH). One outstanding difference from thyroxine-induced swelling was that GSH-induced swelling was not reversible. These studies have been extended by Lehninger and Gotterer (2, 3) with the discovery that GSH-induced swelling is reversed by adenosine triphosphate + Mg ++ + bovine ser...

Lehninger and Schneider (1) studied the swelling of isolat,ed liver mitochondria induced by reduced glutathione (GSH). One outstanding difference from thyroxine-induced swelling was that GSH-induced swelling was not reversible. These studies have been extended by Lehninger and Gotterer (2, 3) with the discovery that GSH-induced swelling is reversed by adenosine triphosphate + Mg ++ + bovine ser...