We report here the silicon isotopic composition (δSi) of dissolved silicon (DSi) from 42 surface water samples from the Drake Passage, the Weddell Gyre, other areas south of the Southern Boundary of the Antarctic Circumpolar Current (ACC), and the ACC near the Kerguelen Plateau, taken between the beginning of February and the end of March 2007. From the beginning to end of the cruise (ANTXXIII/...

Depolarization-induced suppression of inhibition (DSI) is a retrograde form of synaptic inhibition involving the Ca2+-dependent release of cannabinoids from the postsynaptic cell. DSI exerts multiple effects on presynaptic neurons: here, we establish the breakdown of DSI in its individual components at the synapses between basket and stellate cells and Purkinje cells. In the presence of tetrodo...

OBJECTIVES Dual sensory impairment (DSI) is a combination of vision and hearing impairments that represents a unique disability affecting all aspects of a person's life. The rates of DSI are expected to increase due to population aging, yet little is known about DSI among older adults (65+). The prevalence of DSI and client characteristics were examined among two groups, namely, older adults re...

Action potential firing or depolarization of the postsynaptic neuron can induce a transient suppression of inhibitory synaptic inputs to the depolarized neuron in the cerebellum and hippocampus. This phenomenon, termed depolarization-induced suppression of inhibition (DSI), is initiated postsynaptically by an elevation of intracellular Ca2+ concentration ([Ca2+]i) and is expressed presynaptical...

Regulation of synaptic, GABAA receptor-mediated inhibition is a process of critical importance to normal brain function. Recently, we have described a phenomenon in hippocampus of a transient, yet marked, decrease in spontaneous, GABAA receptor-mediated IPSCs after depolarization activated Ca2+ influx into a pyramidal cell. This process, depolarization-induced suppression of inhibition (DSI), i...