Mexiletine as the first choice drug in myotonia treatment is a chiral sodium channel blocker clinically used in its racemic form. The phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster in a chalice-shaped structure. Therefore, the present study reports the synthesis and in-vitro anti-myotonic activity of the chalice-shaped cluster of mexiletine...

Psychological data suggest that internal representations such as mental images can be used as templates in visual pattern recognition. But computational studies suggest that traditional template matching is insufficient for high-accuracy recognition of real-life patterns such as handwritten characters. Here we explore a model for visual pattern recognition that combines a template-matching and ...

Most protein structure prediction methods use templates to assist in the construction of protein models. In this paper, we analyse the current state of template-based modelling approaches and reach an estimate of the empirical limits of these methods. Our analysis show that current prediction methods are already reaching these empirical accuracy limits in the easier cases, where finding a close...

This paper describes a simple and efficient method to make template-based object classification invariant to in-plane rotations. The task is divided into two parts: orientation discrimination and classification. The key idea is to perform the orientation discrimination before the classification. This can be accomplished by hypothesizing, in turn, that the input image belongs to each class of in...

Automated protein structure prediction is becoming a mainstream tool for biological research. This has been fueled by steady improvements of publicly available automated servers over the last decade, in particular their ability to build good homology models for an increasing number of targets by reliably detecting and aligning more and more remotely homologous templates. Here, we describe the t...

We propose a novel method to automatically segment subcortical structures of human brain in magnetic resonance images by using fuzzy templates. A set of fuzzy templates of the structures based on features such as intensity, spatial location, and relative spatial relationship among structures are first created from a set of training images by defining the fuzzy membership functions and by fusing...