The human LARGE gene encodes a protein with two putative glycosyltransferase domains and is required for the generation of functional -dystroglycan ( -DG). Monoclonal antibodies IIH6 and VIA4-1 recognize the functional glycan epitopes of -DG that are necessary for binding to laminin and other ligands. Overexpression of full-length mouse Large generated functionally glycosylated -DG in Pro 5 Chi...

Chronic subcutaneous (s.c.) administration of D-galactose (DG) to BL/6J mice has been shown to induce oxidative stress and is considered a model to mimic accelerated ageing. Fructo-oligosaccharide (FO) is a well-defined prebiotic and its fermentation by lactic acid bacteria has been shown to exert antioxidative capacity. The present study was aimed to determine whether FO attenuated DG-induced ...

Receptors for basement membrane (BM) proteins, including dystroglycan (DG), coordinate tissue development and function by mechanisms that are only partially defined. To further elucidate these mechanisms, we generated a conditional knockout of DG in the epithelial compartment of the mouse mammary gland. Deletion of DG caused an inhibition of mammary epithelial outgrowth and a failure of lactati...

Objective(s): Ceftriaxone (Cef), a beta-lactam antibiotic, is accompanied by antioxidant and anti-inflammatory properties. It has been shown that Cef has beneficial effects on Alzheimer’s disease. In the current investigation, the effect of Cef in a mice model of aging was investigated. Materials and Methods: Forty male mice were equally...

Dystroglycan (DG), a cell adhesion molecule well known to be essential for skeletal muscle integrity and formation of neuromuscular synapses, is also present at inhibitory synapses in the central nervous system. Mutations that affect DG function not only result in muscular dystrophies, but also in severe cognitive deficits and epilepsy. Here we demonstrate a role of DG during activity-dependent...

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [(99m)Tc(H2O)3(CO)3](+) complex. [(99m)Tc]-ECB-DG and [(99m)Tc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na(99m)TcO4 in 1 mL sa...

Abstract. For a (molecular) graph G with vertex set V (G) and edge set E(G), the first and second Zagreb indices of G are defined as M1(G) = ∑ v∈V (G) dG(v) 2 and M2(G) = ∑ uv∈E(G) dG(u)dG(v), respectively, where dG(v) is the degree of vertex v in G. The alternative expression of M1(G) is ∑ uv∈E(G)(dG(u) + dG(v)). Recently Ashrafi, Došlić and Hamzeh introduced two related graphical invariants M...