Background and Objectives: Various studies have shown that sex steroids affect cancer cells at cellular and molecular level. In this study, the anti-proliferation effects of testosterone, was investigated on gastric cancer cell line (AGS) and activity level of caspase-3, -8 and -9, was evaluated.   Methods: In this laboratory experimental study, AGS cell line, were randomly divided into contro...

Background: Many diseases, including diabetes, are involve in the development of liver disorders through changes in the expression of genes such as Caspase-3. In the present study, the impact of alcoholic extract of Alhagi maurorum on the expression level of liver Caspase-3 gene was investigated in male Wistar rats following the induction of diabetes mellitus by streptozotocin. Materials and me...

Introduction: One of the complications of diabetes mellitus is induction of apoptosis in liver tissues. Activation of caspase 3 caused apoptosis in the cells. Garlic is a most common plant in diet that its effect on apoptosis was not determined. In this study the effects of this extract on Bax and Bcl-2 gene expression and the activity of caspase 3, were determined in type 1 and 2 of diabetes i...

بر اساس یافته های بالینی اخیر بیش از 60? از بیماران مبتلا به سرطان از گیاهان به عنوان مکمل در درمان خود استفاده می کنند. گیاه اسپند، peganum harmala l به دلیل وجود آلکالوئیدهایی که دارد دارای خاصیت ضد سرطانی است. هدف از انجام این پایانامه بررسی اثر ضدسرطانی آلکالوئیدهای هارمین و هارمالین اسفند می باشد. آلکالوئیدهای اسپند استخراج و توسط دو تکنیک hplc و ft-ir شناسایی شدند و اثر آنها به عنوان یک ...