Ribosomal attachment to mammalian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of interactions, but the mechanism by which mRNA enters the mRNA-binding channel of the 40S subunit remains unknown. To investigate this process, we recapitulated initiation on capped mRNAs in vitro using a reconstituted translation system. Formation of initiat...

background and aims: neurofeedback is a relatively new therapy focusing on the core symptoms of inattention, impulsivity and hyperactivity.we undertook a meta-analysis to estimate the effectiveness of neurofeedback on attention deficit disorder in iran. methods: international databases of pubmed, scopus, isi, google scholar, and national databases of sid, med lib, iranmedex, magiran were search...

this study was conducted to compare the bio-efficacy of herbal methionine (h-met) relative to dl-methionine (dl-met) on 160 “ross 308” broiler chickens. dl-met and h-met were added to the basal diet in eight experimental treatments with three and four concentrations respectively in starter, grower and finisher period. blood parameters which were measured at 24 and 42 days of age consisted of: s...

Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...

1. Abstract 2. Significance of HGF-Met in molecular target therapy of cancer 3. NK4 as HGF-antagonist 4. Biological activity of NK4 as angiogenesis inhibitor 5. Experimental cancer treatment by gene expression of NK4 5.1. Inhibition of invasion-metastasis associated with Met inactivation by NK4 gene therapy 5.2. NK4 gene therapy using recombinant adenovirus for metastatic cancers 6. Conclusion ...

eShadow is a storytelling tool that can be used from both adults and children in order to create, record, share and watch digital shadow theater plays. It is based on the traditional Greek Shadow Theatre, which has a long history of usage in entertainment and education, particularly pre-school and primary school education. We present our experience from the use of eShadow in the ALICE ALPPs con...

J uvenile hormone (JH) has long been known to be a potent regulator of metamorphosis in most insects, but learning how it acts has been hindered until now by failure to find an entry point for its mechanism of action. Using the beetle Tribolium castaneum, Konopova and Jindra (1) have achieved a result long and fruitlessly sought in Drosophila, which is reported in this issue of PNAS. They have ...