Microcystin-LR (MC-LR) and glyphosate (GLY) have been classified as a Group 2B 2A carcinogens for humans, respectively, frequently found in aquatic ecosystems. However, data on the potential hazard of MC-LR GLY exposure to fish gut are relatively scarce. In current study, subacute toxicity test zebrafish exposed (35 μg L−1) (3.5 mg L−1), either alone or combination was performed 21 d. The resul...

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported the activities several mitochondria-enriched miRNAs regulating inflammation (i.e., miR-142-3p, miR-142-5p, miR-146a) altered in hippocampus at 3–12 hours following a severe traumatic brain injury. In present study, we...

objective(s): to explore the correlation between expression patterns and functions of mir-383 and ldha in hepatocellular cancer (hcc). materials and methods: we detected the expression of mir-383 and ldha in 30 hcc tissues and their matched adjacent normal tissues using qrt-pcr. then we performed mtt assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

Recent studies have revealed the critical role of microRNAs (miRNAs) in regulating cardiac injury. Among them, the cardiac enriched microRNA-1(miR-1) has been extensively investigated and proven to be detrimental to cardiac myocytes. However, solid in vivo evidence for the role of miR-1 in cardiac injury is still missing and the potential therapeutic advantages of systemic knockdown of miR-1 ex...

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role...

Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. Objectives: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. Materials an...

MicroRNA-101 (miR-101) is frequently downregulated in various cancers. To date, the regulatory networks of miR-101 remain obscure. In this study, we demonstrated that miR-101 was mainly transcribed from human miR-101-2 and mouse miR-101bgene loci. Subsequent analyses revealed that activator protein-1 (AP-1) directly binded to the -17.4 to -16.4 k region upstream of pre-miR-101-2 and activated t...

We describe a large-scale and complete experiment aiming at validating the hypothesis that the popularity of music titles can be learnt using global acoustic or human features. We use a 32.000 title database with 632 manually-entered attributes per titles including 3 related to the popularity of the title. We design an experiment with two different audio feature sets, as well as the set of all ...