نتایج جستجو برای: novel coronavirus
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In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the...
The rapid advancement of molecular tools in the past 15 years has allowed for the retrospective discovery of several new respiratory viruses as well as the characterization of novel emergent strains. The inability to characterize the etiological origins of respiratory conditions, particularly in children, led several researchers to pursue the discovery of the underlying etiology of disease. In ...
سخن سردبیر Editorial مجله دانشگاه علوم پزشکی رفسنجان دوره نوزدهم، فروردین 1399، 2-1 جهان و بیماری کرونا ویروس جدید (کووید-19) ) World and the novel coronavirus disease (COVID-19 محسن رضائیان[1]،[2] M.Rezaeian به هنگام تکمیل این سخن سردبیری در بیست و سوم فروردین سال 1399 برابر با یازدهم آوریل سال 2020 میلادی، تقریباً صد روز از گزارش رسمی بیماری جدیدی ...
Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type2 pneumocytes and macrophages), kidney, testisand brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a s...
Background: Coronavirus spike protein N-terminal domains (NTDs) bind sugar or protein receptors. Results:We determined crystal structure of bovine coronavirus NTD and located its sugar-binding site using mutagenesis. Conclusion: Bovine coronavirus NTD shares structural folds and sugar-binding sites with human galectins and has subtle yet functionally important differences from protein-binding N...
The COVID-19 pandemic has affected many people around the globe. Europe, as one of the most seriously affected continents, has been struggling with the novel coronavirus for several months. Obviously, outbreak response management plays a critical role in the impact of the disease. Therefore, in this paper, Malmquist Productivity Index is used to evaluate the performance of the most severely aff...
Rhinoviruses and coronaviruses are recognized as the major causes of the common cold syndrome. The role of these viruses in more serious respiratory illnesses resulting in hospitalization is less well defined. During a winter when influenza A infection was prevalent, 100 elderly adults hospitalized because of cardiopulmonary illnesses were evaluated for rhinovirus and coronavirus infection. Pat...
The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic system to functionally screen for the cap-forming enzymes encoded by severe acute respiratory syndrome (SARS) coronavirus and identified the no...
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