Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and preva...

The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, tra...

Genetic algorithms have gained popularity as effective search procedures for obtaining solutions to traditionally difficult space mission optimization problems. In this paper, a real-coded genetic algorithm is used together with calculus of variations to optimize a trajectory for rendezvous problem. The global search properties of genetic algorithm combine with the local search capabilities of ...

ABSTRACTTuberculosis is an infectious disease which occurs widely in the world and becomes one of the top 10 causes of death worldwide. Mutations of the RpoB gene cause the resistance of Mycobacterium tuberculosis to rifampicin that contributes to the occurrence of MDR-TB. This study aimed to determine the pattern of rpoB gene polymorphisms in the MDR M. tuberculosis in Semarang, Indonesia. Mos...

Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon’t respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropr...

A genetic algorithm is used together with calculus of variations to optimize an interplanetary trajectory for the Bryson-Ho Earth-to-Mars orbit transfer problem. The global search properties of genetic algorithm combine with the local search capabilities of calculus of variations to produce solutions that are superior to those generated with the calculus of variations alone, and these solutions...

The aim of this study was to model the variances and covariances of body weight in Zandi sheep from 60 to 365 days of age using random regression models (RRM). Legendre polynomials of different orders were used to model the direct and maternal covariances. Mean trends were also modeled through a quadratic regression on orthogonal polynomials of age. Homogeneity and heterogeneity of the residual...