background: crimean-congo hemorrhagic fever (cchf) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. hypoxia inducible factor-1α (hif-1α) and vascular endothelial growth factor-a (vegf-a) play an important role both in the inflamma­tory process and plasma leakage. the aim of this study was to de...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

stromal derived factor-a (sdf-1-a) is a cxc chemokine which has been demonstrated as a recruitment factor for leukocytes to the site of inflammation, infection, injury and following stress. this chemokine has been shown to be expressed by liver cells and in liver diseases. hence, the aim of this study was to examine the expression of sdf-1 by hepatocytes in responses to the stress imposed durin...

Abstract Background and Aims Mitophagy activation is crucial for hypoxia signaling in acute kidney injury (AKI). Selective removal of damaged mitochondria mediated through a concerted function coding non-coding RNA expressions. Insights on HIF-1α lncRNA-regulated mitophagy mechanism are not known. The study aims to investigate the role hypoxia-inducible factor 1α (HIF-1α) regulated long (lncRNA...

adult periodontitis is a complex multifactorial disease whose etiology is not well defined. the pro-inflammatory and bone resorption properties of interleukine-1α (il-1α) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. eighty iranian adult patients with periodontitis and 80 iranian controls were investigated in this study. in this study we report that the f...