The tumor suppressor p53 is inactivated by mutation in about half of all tumors, making mutant a prime target for cancer therapy. Missense mutations R248W, R273H and R248Q are included the five most frequent total lead to more than 630 000 new diagnosed cases diseases world every year. These mutations, located at or near protein-DNA interface, inactivation loss direct p53-DNA interactions, caus...

Series of novel dichromophoric cyanine dyes based on 2-aminobenzothiazoles and 3-amino-1,2,4 -triazole have been synthesized in high yields. All the dyes have been classified as disperse dyes. Besides their electronic spectroscopic properties, high dye-uptakes on polyester, excellent fastness properties, highly extinction coefficients, and broad solvatochromic effects have been observed in thes...

Kinesins from the bipolar (Kinesin-5) family are conserved in eukaryotic organisms and play critical roles during the earliest stages of mitosis to mediate spindle pole body separation and formation of a bipolar mitotic spindle. To date, genes encoding bipolar kinesins have been reported to be essential in all organisms studied. We report the characterization of CaKip1p, the sole member of this...

we give the concept of ‘braiding’ for 2-groupoids, and we show that this structure is equivalent tobraided regular, crossed modules.

1

-

In this paper, we introduce the concepts of $2$-isometry, collinearity, $2$%-Lipschitz mapping in $2$-fuzzy $2$-normed linear spaces. Also, we give anew generalization of the Mazur-Ulam theorem when $X$ is a $2$-fuzzy $2$%-normed linear space or $Im (X)$ is a fuzzy $2$-normed linear space, thatis, the Mazur-Ulam theorem holds, when the $2$-isometry mapped to a $2$%-fuzzy $2$-normed linear space...