paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. that is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. the last form is intravenous injections. paracetamol derivedfrom 4-minophenol which is synthesized by acylated the p-acetaminophenol and acetic anhydride.4-aminophenol is t...

Paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. That is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. The last form is intravenous injections. Paracetamol derivedfrom 4-minophenol which is synthesized by acylated the P-acetaminophenol and acetic anhydride.4-aminophenol is t...

The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity. Here we show that acetaminophen and many structurally related compounds bind quinone reductase 2 (NQO2) in vitro and in live cells, establishing NQO2 as a novel off-target. NQO2 modulates the levels of acetamin...

Molecular Modeling of the Metabolism of Acetaminophen and Acetaminophen-like Molecules by Laura Rebecca Hofto Paracetamol, or acetaminophen, is a common analgesic and fever-reducer. There are three major metabolic pathways for acetaminophen in the liver. The final products of each pathway are nontoxic and are excreted by the kidneys. Cresol and similar molecules are competitors with acetaminoph...

BACKGROUND Recent case reports suggest that consumption of ethanol may increase the risk of liver injury induced by acetaminophen (INN, paracetamol). However, this possibility is at odds with previous clinical studies that showed that acute ethanol ingestion could protect against hepatotoxicity by inhibiting CYP-mediated acetaminophen oxidation. We tested the hypothesis that ethanol ingestion c...