The analysis of the balance elastase (MMP-2, MMP-9) and TIMP-4 was performed in order to determine their involvement pathogenesis NEC. A progressive duration NEC with sepsis is accompanied by increased serum concentrations MMP-9, MMP-2 TIMP-4. Increases MMP-2>503 ng/ml, MMP-9>812 ng/ml TIMP-4>1404 can be regarded as statistically significant predictors fatal outcome proposed method for...

Recently, matrix metalloproteinases (MMP), in particular the gelatinases MMP-2 and MMP-9, generally considered as tumor markers for clinical applications. A longitudinal 2-years follow-up survey was performed on dogs with cutaneous tumor. Serum samples were obtained from 22 dogs with different cutaneous tumors and 22 health dogs at the time of surgery and one month, three months and one year af...

Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP...

This study investigated whether the inclusion of a matrix metalloproteinase-9 (MMP-9) responsive sequence in self-assembled peptide-based brain-targeting nanoparticles (NPs) would enhance blood-brain barrier (BBB) penetration when MMP-9 levels are elevated both brain and blood circulation. Brain-targeting peptides were conjugated at N-terminus to MMP-9-responsive peptides, these lipid moiety (c...