نتایج جستجو برای: and doxorubicin
تعداد نتایج: 16830389 فیلتر نتایج به سال:
objective(s):berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. but the effect of berberine on breast cancer has not yet been completely studied. in this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. materials and methods: the antiproliferative effects of berberine and doxorubicin alone and in c...
introduction: doxorubicin is frequently used for treatment of several types of cancer. doxorubicin cardiac toxicity has limited the use of this drug. corticosteroids may prevent doxorubicin induced cardiotoxicity. therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of doxorubicin and dexamethasone. methods: mouse em...
Background and Objectives: Doxorubicin-increased oxidative stress destroys tumors and normal cells, especially in heart tissues. The objective of the present study was to investigate effects of eight weeks of aerobic training and crocin consumption on doxorubicin induced heart tissue oxidative stress in male rats. Materials & Methods: In this experimental study, 50 male rats were randomly div...
Background & Aims: Doxorubicin has been widely used to treat solid tumors and blood malignancies, but its toxicity has limited its application. The aim of the present study was to investigate the protective effects of lactoferrin against doxorubicin toxicity on the main gonad of rats. Materials & Methods: 24 Adult male Wistar rats were divided into four groups. Control group received physiolog...
the protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. doxorubicin toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by elevated serum cpkmb and histopathological observations. tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum cpkmb and a...
Background and Objective: Doxorubicin is one of the most common drugs for chemotherapy. The complications of doxorubicin are cardiac toxicity due to oxidative stress. Cydonia oblonga Miller leaf (COL) contains flavonoids and phenolic antioxidants. Due to the presence of antioxidant compounds in COL, the aim of this study was to evaluate the effect of hydroalcoholic extract of COL on doxorubicin...
recognition of the molecular mechanisms of camp action against dna damage-induced apoptosis can be useful to improve the efficacy of dna damaging therapeutic agents. considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-trea...
Introduction: Doxorubicin is frequently used for treatment of several types of cancer. Doxorubicin cardiac toxicity has limited the use of this drug. Corticosteroids may prevent doxorubicin induced cardiotoxicity. Therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of Doxorubicin and dexamethasone. Methods: Mouse ...
Attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) and doxorubicin. Biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. PLGA nanoparticles were formulated by sonication method. Lactide/glycolide ratio ...
Background: Doxorubicin is one of the most commonly used anticancer drugs. The purpose of this study was to investigate the protective effect of hydroalcoholic extract of Carob (Ceratonia Siliqua) on testicular tissue in adult rats treated with doxorubicin. Materials and Methods: In this experimental study, 56 adult male Wistar rats were used in 8 groups of seven. The control group received...
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