Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Pharmacy teams in both primary and secondary care can support people with epilepsy, the vast majority of whom will be taking one or more anti-seizure medicines (ASMs) to manage their condition. This article is second a series focuses on management epilepsy. Information relating symptoms diagnosis found […]

Objective: Regarding the anticonvulsant effects of Satureja hortensis (S. hortensis) in Avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of S. hortensis aqueous and ethanolic aerial part extracts. Furthermore, the mechanisms of their anticonvulsant activities were also evaluated. Materials and Methods: Seizure was induced by Pentylen...

Background: Seizure disorders are common in infants and children. Cardiac dysrhythmias may manifest clinically as seizure disorders which, if missed, may cause serious consequences. Objective: To investigate the electrocardiogram, conduction and rhythm disturbances in a group of patients in pediatric age group clinically presenting as various types of seizures Methods: We studied electrocardiog...

Let g ∈ Q be not −1 or a square. Let Pg denote the set of primes p such that g is a primitive root mod p. Let 1 ≤ a ≤ f, (a, f) = 1. Under the Generalized Riemann Hypothesis (GRH) it can be shown that the set of primes p ∈ Pg with p ≡ a(mod f) has a natural density. In this note this density is explicitly evaluated. This generalizes a classical result of Hooley.

BACKGROUND The purpose of this work was to determine in a clinical trial the efficacy of reducing or preventing seizures in patients with neurological handicaps through sustained cortical activation evoked by passive exposure to a specific auditory stimulus (particular music). The specific type of stimulation had been determined in previous studies to evoke anti-epileptiform/anti-seizure brain ...

PURPOSE Lack of a potentially epileptogenic lesion on brain magnetic resonance imaging (MRI) is a poor prognostic marker for epilepsy surgery. We present a single-center series of childhood-onset MRI-negative drug-resistant epilepsy (DRE) and analyze surgical outcomes and predictors. METHODS Children with MRI-negative DRE who had resective surgery from January 2007 to December 2013 were ident...

Several studies show that the risk of accidents involving patients with epilepsy is much higher compared to the general population. The objective of this study was to identify the frequency and type of seizure related injuries in children diagnosed with epilepsy. In addition we also assessed possible risk factors associated with this seizure related accidents in childhood. This study was conduc...

AIM Status epilepticus (SE) results in the generation of reactive oxygen species (ROS), which contribute to seizure-induced brain injury. It is well known that oxidative stress plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive monomer extracted from black cumin (Nigella sativa) seed oil that has anti-inflammatory, anti-cancer, and antioxidant activity in various ...