objectives in this study, we aimed to investigate the changes in brain lipidomics following prolonged and intermittent ischemic preconditioning. materials and methods two groups underwent bilateral common carotid artery occlusion either intermittently (for 3 continuous periods within a timeframe of 20 minutes, releasing 3 consecutive times, yielding a total of 9 minutes (intermittent bilateral ...

Objective(s): The purpose of this study was to investigate cytotoxicity and membrane toxicity effects induced by Mesobuthus eupeus venom (MEV) on the HT-29 cell line. Materials and Methods: To determine the in vitro cytotoxicity via MTT assays, HT-29 (as cancer cell line) and Hek-293T (as normal cell) were treated through different conce...

Background and objectives: Prostate cancer is the second leading cause of mortality among men worldwide, and the eighth cancer-related cause of death in Iran. Male sex hormones (androgens) are the main cause of prostate cancer cells. Triptorelin is considered a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) in the treatment of prostate cancer. This study aimed to evalua...

Glioblastoma multiforme (GBM) is the most aggressive brain cancer. We previously demonstrated effect of biocompatible surface functionalized graphene quantum dots (GQDs) on GBM cells as chemotherapy enhancers in combination with antitumor drug doxorubicin (Dox). However, traditional two-dimensional cultures could not represent a reliable model tumor behavior. In this work, we investigated carbo...

Objective: GLUT4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. The muscle is the major site of GLUT4 and cell line models, to explore GLUT4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. Here, C2C12 cell line is evaluated for GLUT4 translocation from intracellular compartment into the cell membrane...

BACKGROUND Mesenchymal stem cells (MSCs) are ideal candidates for treatment of diseases. Amniotic membranes are an inexpensive source of MSCs (AM-MSC) without any donor site morbidity in cell therapy. Adipose tissue derived stem cells (ASCs) are also suitable cells for cell therapy. There is discrepancy in CD271 expression among MSCs from different sources. In this study, the characteristics...

Membranes made up of composite materials have shown promising advantages for application in alkaline fuel cell anion exchange membranes. In this study, a general method is employed to improve the overall performance and properties membranes by making use polyethersulfone quaternized with imidazolium groups blended functionalized graphene oxide inorganic filler (ImGO). The polymer matrix yielded...

Polymer Electrolyte Membrane Fuel Cells (PEMFC) are currently considered the most advanced fuel cell technology. However, industrial implementation of PEMFCs is strongly hindered by deficient durability, especially that carbonaceous materials commonly used to support platinum-based catalyst nanoparticles, which prone electrochemical corrosion at cathode, resulting in a serious performance loss ...