Currently high risk locally advanced rectal cancer (LARC) patients (pts) are treated with intensified neoadjuvant chemotherapy and radiation (TNT). The previous study SAKK 41/08 showed that adding Sorafenib to long course chemoradiation (LcCRT) is highly active. This potential improvement in clinical outcome by a multi-TKI as Regorafenib (R) LcCRT was investigated the 41/16 trial. Pts T3-4 and/...

Achieving business-IT alignment is one of the main purposes and also challenges of organizations. Many studies have indicated the importance of aligning information systems (IS) function with other business functions. The main purpose of this survey is evaluating business-IT alignment focusing on social and technical dimensions of business-IT alignment in Bank Mellat. The data was collected thr...

BACKGROUND AND OBJECTIVE Hb Lepore is a structurally abnormal hemoglobin in which the abnormal globin chain is a hybrid or fused globin chain (db). Three different Lepore hemoglobins have been identified, differing from each other in the point at which the db fusion occurs; Hb Lepore Hollandia (d22/b50), Hb Lepore Baltimore (d59/b86) and Hb Lepore Boston (d87/b116). In Spain only Hb Lepore Bost...

Background Individual response to immune checkpoint inhibition (ICI) in patients with metastatic melanoma varies from 10–40% for monotherapy and 50–60% combination therapy [1]. Identification of adjuncts ICI further bridge treatment cure is imperative. We focus on caloric restriction (CR) as an adjunct anti-PD-1 given its inexpensive nature, relative ease application, increased tolerability com...

On 1996 March 14È15 we conducted a campaign with the Hubble Space Telescope GHRS to observe the Si IV jj1394, 1403 lines of the B0.5e star c Cas at high temporal and spectral resolution. As a part of this D22 hr campaign, the Rossi X-Ray T iming Explorer (RXT E) was also used to monitor this starÏs copious and variable X-ray emission. In this fourth paper of a series we present an analysis of t...

This thesis concerns the analysis of multivariate data. The amount of data that is obtained from various sources and stored in digital media is growing at an exponential rate. The data sets tend to be too large in terms of the number of variables and the number of observations to be analyzed by hand. In order to facilitate the task, the data set must be summarized somehow. This work introduces ...

Introduction The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a serious condition associated with persistently high ADH water retention despite sufficient vascular volume. Sodium valproate (VPA), an antiepileptic indicated to treat bipolar disorder, blocks sodium (Na) and calcium ions. Few studies have examined the association between VPA SIADH. Objectives This abstract h...

Accurate models of protein diffusion are important in a number of applications, including liquidliquid phase separation and growth of protein crystals for X-ray diffraction studies. In concentrated multicomponent protein systems, significant deviations from pseudobinary behavior can be expected. Rayleigh interferometry is used to measure the four elements (Dij)v of the ternary diffusion coeffic...