Background: Matrix metalloproteinase-9 (MMP-9) expression has been implicated in molecular mechanisms of neurodegenerative disorders, and its abnormal level has been reported in Alzheimer’s disease (AD). Some protective mechanisms of statins against neurodegeneration might be mediated by the inhibition of MMP-9 expression. Here, we investigated the effect of simvastatin, on the hippocampal MMP-...

Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...

Knowledge on the role of matrix metalloproteinases (MMPs) in adenoid cystic carcinoma (ACC) is limited. MMPs are capable degrading almost all extracellular and pericellular components to promote invasion metastasis. This study aimed evaluate immunohistochemical expression MMP-7, -8, -9, -15, -25 ACC relate results with clinicopathological factors survival. The included 68 patients minor salivar...

Background Around 8–10% of individuals over 50 years age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain. Methods From 817 recruited in our ageing programme at the Mexican National Institute Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 same cohort normal high-resolution computed tomography to evaluate demographic functional differen...