نتایج جستجو برای: nqo1

تعداد نتایج: 1144  

بخشی, ام البنین, حسینی, وحید, حقی امینجان, حامد, شکرزاده, محمد, صالح طبری, یحیی, محمدپور, عباس,

Background and purpose: Gastric cancer is the second most common cause of cancer worldwide and despite huge advances in treatments, the chance of survival is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. Polymorphisms in the NQO1(NAD(P)H Quinone dehydrogenase 1) gene could affect the activity of the gene and also the susceptibilit...

Cataract is multi-factorial eye disease identified by the disturbance of the transparent ocular lens. There is significant evidence suggesting oxidative damage as a major cause of initiation and progression of numerous diseases including cataracts. NAD(P)H:quinone oxidoreductase 1 (NQO1; OMIM: 125860) and catalase (CAT, OMIM: 115500) are antioxidant enzymes that prevent cells from oxidative str...

NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. NQO1 C609T polymorphism is a strong determinant of NQO1 structure and function. The people with mutant allele for this polymorphism has significantly reduced NQO1 activity. In this study, we tried to evaluate the risk of lung cancer as...

Journal: :Molecular pharmacology 2001
D Siegel A Anwar S L Winski J K Kepa K L Zolman D Ross

The NAD(P)H:quinone oxidoreductase 1 (NQO1)*2 polymorphism is characterized by a single proline-to-serine amino acid substitution. Cell lines and tissues from organisms genotyped as homozygous for the NQO1*2 polymorphism are deficient in NQO1 activity. In studies with cells homozygous for the wild-type allele and cells homozygous for the mutant NQO1*2 allele, no difference in the half-life of N...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
J L Moran D Siegel D Ross

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding s...

Journal: :Molecular pharmacology 2004
David Siegel Daniel L Gustafson Donna L Dehn Jin Yi Han Preecha Boonchoong Lawrence J Berliner David Ross

Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1:1 stoichiometry of oxygen consumption to NADH oxidation with the production of hydrogen peroxide. The rate of auto-oxidation of fully reduced NQO1 was markedly accelerated in the presence of superoxide (O(2)(*)(-)), whereas the addition o...

2015
Joseph M. Wu Ardalan Oraee Barbara B. Doonan John T. Pinto Tze-chen Hsieh

BACKGROUND The NAD(P)H quinone oxidoreductase (NQO1) confers protection against semiquinones and also elicits oxidative stress. The C609T polymorphism of the NQO1 gene, designated NQO1*2, significantly reduces its enzymatic activity due to rapid degradation of protein. Since down regulation of NQO1 mRNA expression correlates with increased susceptibility for developing different types of canc...

Journal: :Cancer research 2003
Alison K Bauer Brenda Faiola Diane J Abernethy Rosemarie Marchan Linda J Pluta Vicki A Wong Kay Roberts Anil K Jaiswal Frank J Gonzalez Byron E Butterworth Susan Borghoff Horace Parkinson Jeffrey Everitt Leslie Recio

Enzymes that activate and detoxify benzene are likely genetic determinants of benzene-induced toxicity.NAD(P)H: quinone oxidoreductase-1 (NQO1) detoxifies benzoquinones, proposed toxic metabolites of benzene. NQO1 deficiency in humans is associated with an increased risk of leukemia, specifically acute myelogenous leukemia, and benzene poisoning. We examined the importance of NQO1 in benzene-in...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2011
Brian J Lindemer Robert D Bongard Raymond Hoffmann Shelley Baumgardt Frank J Gonzalez Marilyn P Merker

The quinones duroquinone (DQ) and coenzyme Q(1) (CoQ(1)) and quinone reductase inhibitors have been used to identify reductases involved in quinone reduction on passage through the pulmonary circulation. In perfused rat lung, NAD(P)H:quinone oxidoreductase 1 (NQO1) was identified as the predominant DQ reductase and NQO1 and mitochondrial complex I as the CoQ(1) reductases. Since inhibitors have...

2014
Seung Taek Nam Jung Hwan Hwang Dae Hong Kim Mi Jung Park Ik Hwan Lee Hyo Jung Nam Jin Ku Kang Sung Kuk Kim Jae Sam Hwang Hyo Kyun Chung Minho Shong Chul-Ho Lee Ho Kim

NADH:quinone oxidoreductase 1 (NQO1) is known to be involved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders. Here, we show for the first time that compared to NQO1-WT mice, NQO1-KO mice exhibited a marked increase of permeability and spontaneous inflammation in the gut. In the DSS-induced colitis model, NQO1-K...

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