Verschiedene Untersuchungen belegen, dass die beiden mRNA-Impfstoffe mRNA-1273 (Moderna) und BNT162b2 (Pfizer/BioNTech) immunsupprimierte Menschen vor Infektionen mit der SARS-CoV-2-Deltavariante (B.1.617.2) schützen. Gilt dies auch für Omikron-Variante (B.1.1.529)? Dieser Frage ging ein US-Forscherteam mithilfe einer retrospektiven Kohortenstudie nach.

Interest in hydroxy - carboxylic acid 2 (HCA2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. The present study aimed to evaluate the presence of mRNA of this receptor in different organs of laboratory rat. Twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...

Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL.  Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as contro...

Introduction: Although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. The objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (CEA) mRNA and lung-specific X protein (LUNX) mRNA biomarkers in peripheral blood to detect lung cancer individually and simultaneously. Met...

Ongoing research into the use of messenger RNA (mRNA) vaccines for treatment cancer has been expediated by coronavirus pandemic because similar technology was used in development mRNA COVID‐19 vaccines. So how close are we now to widespread clinical anti‐cancer vaccines?

Increasing importance of vaccination during coronavirus disease 2019 (COVID-19) pandemic, several vaccines were developed. Messenger RNA (mRNA) including BNT162b2 (Pfizer, New York, NY, USA; BioNTech, Mainz, Germany), mRNA-1273 (Moderna, Cambridge, MA, USA) have been disclosed side effects such as thrombocytopenia, myocarditis and headache in general. In addition, adverse due to autoimmune resp...