The overall goal of this method is to record single-unit responses from an identified population of neurons. In vivo electrophysiological recordings from individual neurons are critical for understanding how neural circuits function under natural conditions. Traditionally, these recordings have been performed 'blind', meaning the identity of the recorded cell is unknown at the start of the reco...

In recent years, recording neuronal activity in the awake, behaving primate brain has become established as one of the major tools available to study the neuronal specificity of the initiation and control of various behaviors. Primates have traditionally been used in these studies because of their ability to perform more complex behaviors closely akin to those of humans, a desirable prerequisit...

GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...

Typically, long-term potentiation (LTP) has been assessed as long-lasting changes in field potentials or intracellularly recorded postsynaptic potentials evoked by activation of a set of afferents. In the present experiment, we determined changes in spontaneous unit activity in the dentate gyrus (DG) following high-frequency (HFS) or low-frequency stimulation (LFS) of the medial perforant pathw...

We have adapted for use in fish several of the procedures employed for recording single neuron activity in freely behaving rodents. Developing a method for single unit chronic recording in freely behaving fish was motivated by a need for a comparison across taxa of telencephalic neural activity evoked during spatial navigation by animals of their environments. However, the procedures outlined h...

The data which have emerged from single-unit recordings of thermally sensitive neurons in the hypothalamus are reviewed. Although these neurons may be important components in the central control of body temperature, the interpretation of the data is fraught with uncertainties. The neurons in question could be primary thermosensors or part of an integrative network. There is a notable lack of co...

Cortical neurons have been reported to use both rate and temporal codes. Here we describe a novel mode in which each neuron generates exactly 0 or 1 action potentials, but not more, in response to a stimulus. We used cell-attached recording, which ensured single-unit isolation, to record responses in rat auditory cortex to brief tone pips. Surprisingly, the majority of neurons exhibited binary ...

Several studies revealed that orexins may take part in the regulation of the different forms of affective and cognitive processes during wakefulness. The orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) as an important part of the prefrontal cortex (PFC) have a crucial role in cognitive processes such as reward and decision-making and has a high density of orexin receptor type 1 (...