There is considerable evidence that pregnancy changes the disposition of drugs in an enzymeand gestational stage–specific manner. On the basis of probe drug studies, the activity of CYP3A4 and CYP2D6 increases and CYP1A2 decreases during human pregnancy. However, no studies of CYP2B6 activity during human pregnancy have been conducted. In rodent models and in HepG2 cells, CYP2B enzymes have bee...

strain energy is smaller on (101)/(104) planes than on the (003) plane, which might determine the more favorable crystal growth on (101)/(104) planes in our film. Only micro-Raman spectroscopy has been useful to identify LiCoO2 film patterning. In addition to the strong and sharp bands around 730 and 380 cm of the spectrum from the PTFE membrane in Figure 3b, two Raman active vibrational modes ...

This work presents the fastest Current Mode Logic static frequency divider to date. The circuit is fabricated in a commercially available InP process. Microwave techniques are used to achieve speeds of 75 GHz without resort to emitter followers. Interconnect design is stressed and the results of several variations are presented. Microstrip, inverted microstrip, peaking inductors and keep-alive ...

P2X receptors and nicotinic acetylcholine receptors (nAChRs) display functional and physical interactions in many cell types and heterologous expression systems, but interactions between a6b4-containing (a6b4*) nAChRs and P2X2 receptors and/or P2X3 receptors have not been fully characterized. We measured several types of crosstalk in oocytes coexpressing a6b4 nAChRs and P2X2, P2X3, or P2X2/3 re...

We present a microfluidic approach for single-molecule studies of the temperature-dependent behavior of biomolecules, using a platform that combines microfluidic sample handling, on-chip temperature control, and total internal reflection fluorescence (TIRF) microscopy of surface-immobilized biomolecules. With efficient, rapid, and uniform heating by microheaters and in situ temperature measurem...