PURPOSE Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experiments. METHODS We designed and synthesized MDAP(1000), MDAP(3000), and MDAP(5000), which consist ...

Improvements in life expectancy have been considerable over the past hundred years. Forecasters have taken to applying historical trends under an assumption of continuing improvements in life expectancy in the future. A linear mixed effects model was used to estimate the trends in global and regional rates of improvements in life expectancy, child, adult, and senior survival, in 166 countries b...

studies pertaining convergence and its benefits for developing and underdeveloped countries, specifically latin american countries and the caribbean islands are essential because they can create the necessary grounds for further growth and development. the aim of this study is to analyze the economic growth of latin american countries and the caribbeans after their beta and sigma convergences d...

BACKGROUND Few studies have investigated ambulance utilization in people aged 85 years or older, ie, the oldest old. METHODS We conducted a 1-year population-based observational study of patients transported by ambulance to emergency departments in Tokyo, Japan, which has a population of about 12 million. Demographic data, symptoms/events associated with ambulance transport, and the proportio...

5.9 million children under age five died in 2015, 16 000 every day. Globally, under-five mortality rate has decreased by 53%, from an estimated rate of 91 deaths per 1000 live births in 1990 to 43 deaths per 1000 live births in 2015. The average annual rate of reduction in under-five mortality has accelerated from 1.8%  a year over the period 1990–2000 to 3.9%  for 2000–2015 , but remains insuf...

We evaluated the ability of the combination disk test (CDT) and the Modified Hodge Test (MHT) to discriminate between various carbapenemase-producing Pseudomonas aeruginosa isolates (KPC, n = 36; metallo-β-lactamase (MBL), n = 38) and carbapenemase non-producers (n = 75). For the CDT, the optimal inhibitor concentrations and cut-off values were: 600 μg of 3-aminophenylboronic acid (APB) per dis...