PURPOSE Competing risks observations, in which patients are subject to a number of potential failure events, are a feature of most clinical cancer studies. With competing risks, several modeling approaches are available to evaluate the relationship of covariates to cause-specific failures. We discuss the use and interpretation of commonly used competing risks regression models. EXPERIMENTAL D...

For NASA quality assurance managers, obtaining an accurate, program-wide picture of software safety risk is difficult across the multiple, independently-developing systems in the NASA Constellation program. In this study, we create metrics that leverage one source of safety information, hazard analysis, to provide NASA quality assurance managers with information regarding the ongoing state of s...

Background and aims: Chronic kidney disease (CKD) is a public health challenge worldwide, with adverse consequences of kidney failure, cardiovascular disease (CVD), and premature death. Chronic kidney disease leads to the end stage of renal disease (ESRD), if late/not diagnosed. Competing risk modeling is a major issue in Epidemiology research. In Epidemiology study, sometimes inappropriate met...

background economic consequence analysis is vital for recognizing pipeline comprehensive risk analysis and emergency response planning. objectives the purpose of this study was to estimate economic loss due to fire and explosion in petrochemical feed and product pipelines. materials and methods the present study which performed on 47 pipelines of a petrochemical special zone, pertinent pipeline...

Introduction: Today, with development of various industries, the adverse events originated from explosion and emission of toxic and chemical substances have increased. These events may cause serious environmental problems that threaten human health and safety. Therefore, knowledge about the risk of toxic substances from industrial facilities is essential. Although, chlorine is extensively uti...

Modeling and analysis of high consequence, high assurance systems requires special modeling considerations. System safety and reliability information must be captured in the models. Previously, high consequence systems were modeled using separate, disjoint models for safety, reliability, and security. The MultiGraph Architecture facilitates the implementation of a model integrated system for mo...

The general trend towards complex technical systems with embedded software results in an increasing demand for dependable high quality software. The UML as an advanced object-oriented technology provides in principle the essential concepts which are required to handle the increasing complexity of these safety-critical software systems. However, the current and forthcoming UML versions do not di...