Figure 1. Scheme of a kinetic model of central intracellular metabolism. Red arrows indicate glycolysis, magenta pentose-phosphate pathway, green gluconeogenesis, and blue tricaboxylic acid (TCA) cycle. Black arrows indicate exchanges with metabolites, external with respect to the model variables: glc (glucose), g6p (glucose 6-phosphate), f6p (fructose 6phosphate), fbp (fructose phosphate), g3p...

Purpose: To investigate the effect of curcumin on microcystin-LR (MC-LR)induced renal oxidative damage in Balb/c mice. Methods: 40 male Balb/c mice were assigned randomly to 4 groups each having 10 mice. One group served as normal (saline treated) while another group was used as curcumin control. The third group was given MC-LR and used as toxin control. The fourth group was pre-treated with cu...

BACKGROUND Kaposi sarcoma (KS) occurs mainly in immunocompromised patients and is strongly associated with infection with human herpesvirus 8 (HHV-8; also known as "KS-associated herpesvirus"). We hypothesized that KS is linked to deficiencies in specific anti-HHV-8 T cell immunity. METHODS We studied asymptomatic HHV-8 carriers coinfected with human immunodeficiency virus (HIV; n = 23) and p...

Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed based on experimental data in the past stood the test of time and have been, ...

Bacterial genes defining intrinsic resistance to antibiotics encode proteins that can be targeted by antibiotic potentiators. To find such genes, a transposon insertion library of Acinetobacter baylyi was screened with subinhibitory concentrations of various antibiotics to find supersusceptible mutants. A DNA microarray printer was used to replica plate 10,000 individual library clones to selec...

Abstract. The El Niño–Southern Oscillation (ENSO) modulates the lightning flash density (LFD) variability over India during premonsoon, monsoon and postmonsoon seasons. This study intends to shed light on impact of ENSO phases LFD Indian subcontinent using data obtained from Optical Transient Detector (OTD) Lightning Imaging Sensors (LIS) onboard Tropical Rainfall Measuring Mission (TRMM) satel...