نتایج جستجو برای: splicing modulation
تعداد نتایج: 176802 فیلتر نتایج به سال:
Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. The phenotype of HED is associated with mutation in EDA, EDAR, EDARADD and NEMO genes, all of them disruptingNF-κB signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. ...
the determination of the optimal distribution of the catalytic activity profile, whichmaximizes the catalytic effectiveness, in created unsteady state conditions, is analyzed andtreated numerically for the case of a simple reaction. it was proven that the modulation, of thetemperature and the reactant concentration of the external bulk fluid, leads to a considerableincrease of the catalytic eff...
Using TSG101 pre-mRNA, we previously discovered cancer-specific re-splicing of mature mRNA that generates aberrant transcripts/proteins. The fact is aberrantly re-spliced in various cancer cells implies there must be an important mechanism to prevent deleterious on the spliced normal cells. We thus postulated controlled by specific repressors, and searched for repressor candidates siRNA-based s...
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