Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which have been developed more than 30 years ago, have undesirable toxic side effects and most of them show drug-resistance. T...

The behavior of spider monkeys (Ateles geoffroyi) at sleeping sites and the characteristics of these sites were studied in Santa Rosa National Park, Costa Rica. The spider monkeys tended to congregate just prior to dusk at a number of sleeping sites which were repeatedly used (81.6%), but occasionally they slept in trees which were only used once (18.4%). All of the regularly used sleeping tree...

background: there is conflicting reports on the respiratory health effects of indoor risk factor exposure. the aim of this study was to assess the association of indoor environmental factors to pulmonary function in an adult population in zunyi city of southwest china. methods: between july and sep 2012, we conducted a cross-sectional survey of people aged ≥18 yr in 11 inner-city areas of zunyi...

Background & Aims: Substance abuse by adolescents is one of the most important health challenges throughout the world. This study was performed to estimate the prevalence of cigarette smoking, alcohol drinking and illegal drugs use among Iranian adolescents. Method: A total of 2538 secondary and high school students were selected through cluster sampling from 10 provinces in Iran and were surve...

African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue of DB829, is the second simple diamidine found to cure mice with central nervous system infections by a parenteral route of administration. 28DAP010 showed efficacy similar...

The recent announcement that WHO has approved the use of a combination of nifurtimox and eflornithine to treat chronic Gambian sleeping sickness, caused by Trypanosoma brucei gambiense, is a welcome step in the seemingly interminable process of searching for less toxic drugs to treat this devastating disease [1]. Arsenical drugs were first used in 1905; melarsoprol remains the drug most frequen...

background: opioid drugs are the most effective drugs for the treatment of moderate to severe pain. rates of opioid use are influenced by a variety of factors. the aim of this study was to determine the pattern of use of parenteral opioid drugs in hospitalized patients in a referral teaching hospital. methods: in a retrospective study, required data were extracted from medical records of adult ...