We employed gentamicin-sensitive and -resistant derivatives of Escherichia coli in a macrophage phagocytosis assay that compared lambda bacteriophage and gentamicin as extracellular bactericidal agents. Colony counts and direct microscopic examination of phagocytized E. coli supported the conclusion that gentamicin entered macrophages, even at low concentrations, and contributed to their bacter...

Multidrug-resistant bacteria are becoming more common and due to their multiplicity of mechanisms, they are frequently resistant to many if not all of the current antibiotics. This daunting spectre has been the target of many research efforts into conventional antibiotics and alternative approaches. This review focuses on the more recent advances in these fields with an overview on peptidomimet...

The association between anti–lysosome-associatedmembrane protein 2 (LAMP-2) autoantibodies and vasculitis is not new; it dates back to work by Kain et al.1 in 1995 that identified LAMP-2 as a target of antineutrophil cytoplasmic antibodies (ANCA) in 14 of 16 patients with a pauci-immune necrotizing crescentic glomerulonephritis. LAMP-2 makes an intriguing target for ANCA; it is a major constitu...