نتایج جستجو برای: introductionin general
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IntroductionIn 2019, we published the results of a Phase IIb randomized controlled trial putaminal encapsulated porcine choroid plexus cell (termed NTCELL®) administration in patients with Parkinson's disease. This study failed to meet its primary efficacy end-point change UPDRS part III score ‘off’ state at 26-weeks post-implant. However, number secondary end-points reached statistical signifi...
IntroductionIn Parkinson's disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid progression mortality. This often reflected by an increased drop-out rate PD patients in longitudinal studies. Active physical behavior can impact course beneficially has overall positive effect on health. Contrarily, sedentary PD. The aim thi...
abstract given the importance of the text’s formal aspects, in addition to its content, poetry presents special challenges to translators. poetry has its own distinctive features that cannot be rendered into another language easily. the translation of poetry into poetry entails preserving the rhyme, figurative language and the general tone of the original. the present study was an attempt to i...
IntroductionIn 2018, durvalumab was approved by the U.S. Food and Drug Administration as consolidation immunotherapy for patients with stage III NSCLC after definitive chemoradiotherapy (CRT). However, whether benefits EGFR-mutated remains unknown.MethodsWe conducted a multi-institutional retrospective analysis of unresectable who completed concurrent CRT. Kaplan-Meier analyses evaluated progre...
this thesis deals essentially (but not from all aspects) with the extension of the notion of semigroup compactification and the construction of a general theory of semitopological nonaffine (affine) transformation semigroup compactifications. it determines those compactification which are universal with respect to some algebric or topological properties. as an application of the theory, it is i...
abstract the aim of this study was threefold: (1) to investigate the relationship between knowledge of semantic prosody and efl learners general language proficiency; (2) to examine the relationship between qualitative as well as quantitative knowledge of words, and (3) to compare the performance of efl learner on receptive and productive measures of semantic prosody. the study is based on a...
IntroductionIn response to global outbreaks of infectious diseases, the need for support from organizations such as World Health Organization Global Outbreak Alert and Response Network (GOARN) is increasing. Identifying obstacles needs applicants could increase GOARN deployments Japan.MethodsThis cross-sectional study involved a web-based, self-administered questionnaire survey targeting Japane...
IntroductionIn advanced epithelial ovarian cancer (EOC), longer time-interval from surgery to initiation of adjuvant chemotherapy (TITC) is associated with decreased survival. Adding upper abdominal surgical procedures (UAP) increases rates both complete gross resection and postoperative complications in EOC. Our objective was investigate the association UAP TITC. Moreover, if specific monitori...
IntroductionIn the JAVELIN Lung 200 trial, avelumab (anti-programmed death-ligand 1 [PD-L1] antibody) did not significantly prolong overall survival (OS) versus docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report greater than 2-year follow-up data.MethodsPatients stage IIIB or IV recurrent NSCLC disease progression after platinum-doublet chemotherapy were randomized 1:1 to 10 mg...
IntroductionIn CheckMate 227 (NCT02477826), patients with treatment-naive stage IV or recurrent NSCLC and 1% greater tumor programmed death ligand 1 expression had significantly improved overall survival nivolumab plus ipilimumab versus chemotherapy. We present the patient-reported outcomes (PROs).MethodsPatients (N = 1189) were randomized to ipilimumab, nivolumab, PROs exploratory. Changes in ...
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