This prospective study was aimed at a qualitative and quantitative analysis of life events in depression and mania and to find out any correlation between the severity of life events and magnitude of illness. Forty two patients with first episode mania and thirty patients with first episode depression, satisfied the DSM III R Diagnostic Criteria were interviewed using Presumptive Stressful Life...

The prevalence of depression increases substantially during adolescence. Several predictors of major depressive disorder have been established, but their predictive power is limited. In the current study, the feedback negativity (FN), an event-related potential component elicited by feedback indicating monetary gain versus loss, was recorded in 68 never-depressed adolescent girls. Over the foll...

Repeated experiences with major depressive disorder (MDD) may strengthen associations between negative thinking and dysphoria, rendering negative cognition more accessible and pronounced with each episode. According to cognitive theory, greater negative cognition should lead to a more protracted episode of depression. In this study of 121 adults with MDD, number of previous episodes was associa...

Data from middle-aged civil servants in the Whitehall II Study suggest that working long hours of overtime may predispose workers to major depressive episodes.

CONTEXT Episode remission in unipolar major depression, while distinguished by minimal symptom burden, can also be a period of marked sensitivity to emotional stress as well as an increased risk of relapse. OBJECTIVE To examine whether mood-linked changes in dysfunctional thinking predict relapse in recovered patients who were depressed. DESIGN In phase 1 of this study, patients with major ...