AIM The cysteine protease cathepsin K (CatK), abundantly expressed in osteoclasts, is responsible for the degradation of bone matrix proteins, including collagen type 1. Thus, CatK is an attractive target for new anti-resorptive osteoporosis therapies, but the wider effects of CatK inhibitors on bone cells also need to be evaluated to assess their effects on bone. Therefore, we selected, among ...

Background: In kidney transplantation (Ktx) recipients, cardiovascular (CV) disease remains the leading cause of death. Abnormal carotid intima-media thickness (IMT) represents a valid indicator incipient atherosclerosis also in this setting. Cathepsin-K (CatK) is cysteine protease involved vascular remodelling, as well progressive atherosclerosis. study we evaluated clinical predictors CatK Kt...

Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, selective ectosteric sites were identified that are remote from the active site. Inhibitors targeting these ectosteric sites are collagenase selecti...

PURPOSE Mechanisms governing the cellular interactions with well-defined nanotopography are not well described in vivo. This is partly due to the difficulty in isolating a particular effect of nanotopography from other surface properties. This study employed colloidal lithography for nanofabrication on titanium implants in combination with an in vivo sampling procedure and different analytical ...

In this paper we take up again the deformation theory for K-linear pseudofunctors initiated in [4] with a two-fold purpose. Firstly, we introduce the notion of weak 2-cosemisimplicial object in a 2-category and show that the deformation complex X•(F) introduced in [4] can be obtained from one such object in the 2-category CatK of small K-linear categories. In doing this, we describe a family of...