Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A. The complication was less frequent than that of nephrotoxicity, was as easily manageable with reductions in the cyclosporin A dosage, and generally did not cause cli...

Aim: Deltamethrin (DM) is an insecticide and widely used around the world. Rosmarinic acid (RA) found in herbs spices Lamiaceae (mint) family has antioxidant, antiinflammatory antiapoptotic effects. We objective to examine protecting efficacy of preventing toxic effects Deltamethrin. Material Methods: In ours study we 28 male rats. Group 1: Control group, 2: RA was given 20 mg/kg peroral (p.o.)...

BACKGROUND Hepatotoxicity due to drugs is the most common cause of deaths. Nephrotoxicity of the drugs is usually associated with the drugs accumulation in renal tissue. Paromomycin sulfate (PMS) is an anti-leishmania drug. Although the topical approach for the treatment of leishmania is attractive, its use might cause nephrotoxicity and hepatotoxicity. OBJECTIVES This study aimed to evaluate...

Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating wide variety tumors. However, ETP induced hepatotoxicity nephrotoxicity limits its clinical use. This study aims to investigate protective potential taurine (Tau) mitigated histopathological changes in liver kidneys female albino rats treated with ETP. A total 18 were divided into t...

the present study was conducted to evaluate the protective effect of methanolic leaf extract of caesalpinia bonduc (l.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . a control group (saline, group i, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups ii, iii and iv). the effect of methanolic leaf extract of caesalpinia bonduc (grou...

The present study was conducted to evaluate the protective effect of methanolic leaf extract of Caesalpinia bonduc (L.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . A control group (saline, group I, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups II, III and IV). The effect of methanolic leaf extract of Caesalpinia ...

*Agency for Toxic Substances and Disease Registry. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles. Effect of polybrominated biphenyls, B-naphthoflavone and phenobarbital on arylhydrocarbon hydrolase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice. Toxicology 31:343-352. An overview of comm...

BACKGROUND The emergence of highly active antiretroviral therapy (HAART) has dramatically improved quality of life in prolonging survival of human immunodeficiency virus (HIV)-infected patients on treatment in developed as well as developing countries. However, the main shortcoming of HAART in long-term use is its potential to cause liver and kidney derangements that may be life threatening. Th...

Objective(s): The drinking of ethanol causes the wide range of clinical illness and morphological changes including hepatotoxicity and nephrotoxicity. In the current study, the protective properties of crocin versus oxidative stress, apoptosis and inflammation induced by ethanol were assessed. Materials and Methods: The male Wistar rats ...